PERIPHERAL T‐CELL LYMPHOMAS INVOLVING CENTRAL NERVOUS SYSTEM: A REPORT FROM THE CZECH LYMPHOMA STUDY GROUP REGISTRY

Introduction: We analyzed the incidence, risk factors of central nervous system (CNS) relapse and outcome CNS involvement in patients with peripheral T-cell lymphomas (PTCL) prospectively observed Czech Lymphoma Study Group Registry (NCT03199066). Methods: Out 1040 we identified 29 (2.79%) involvement: 13 (1.25%) had disease at initial diagnosis 16 (1.54%) relapse. Median age was 61 years 54.5 years. Initial concurrently systemic lymphoma documented 11 12 patients. The incidence meningeal comparable relapsed (9 vs 11). Most common histology PTCL not otherwise specified (10 cases 8 relapse). prophylaxis used PTCL. High dose methotrexate based treatment administered 44.8% disease. Results: follow-up all 71.3 months. progression-free survival (PFS) 32.6 months, 4.8 months 5 Risk for included: more than one extranodal site (p = 0.008), soft tissue 0.003), testicular 0.046) presence B symptoms 0.035). overall (OS) 46 18.2 11.8 outside 18,9 associated a significantly worse OS compared relapsed/refractory without 0.072). Conclusions: is low concurrent found most these prognosis poor, however, Optimal yet defined. Keywords: Aggressive non-Hodgkin No conflicts interest pertinent to abstract.